Mouse Srebf2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Srebf2
Locus ID	20788
Kit Components	GA204104G1, Srebf2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204104G2, Srebf2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204104G3, Srebf2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_033218
Synonyms	AI608257; bHLHd2; lop13; nuc; SREBP-2; SREBP2; SREBP2gc
Summary	Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.[UniProtKB/Swiss-Prot Function]

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