Mouse Klf10 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Klf10
Locus ID	21847
Kit Components	GA204348G1, Klf10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204348G2, Klf10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204348G3, Klf10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001289471, NM_013692, NM_001357677
Synonyms	AI115143; Egral; EGR[a]; Gdnfif; mGIF; Tieg; TIEG-1; Tieg1
Summary	Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis.[UniProtKB/Swiss-Prot Function]

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