Mouse Fbxl12 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fbxl12
Locus ID	30843
Kit Components	GA205275G1, Fbxl12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205275G2, Fbxl12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205275G3, Fbxl12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001002846, NM_001286529, NM_001286530, NM_013911
Synonyms	3110048D16Rik; Fbl12
Summary	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity).[UniProtKB/Swiss-Prot Function]

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