Mouse Gne activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Gne
Locus ID	50798
Kit Components	GA205376G1, Gne gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205376G2, Gne gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205376G3, Gne gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001190414, NM_015828, NM_001357539
Synonyms	2310066H07Rik; DMRV; GLCNE; IBM2; NM; Uae1
Summary	Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Required for normal sialylation in hematopoietic cells (By similarity). Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. Plays an essential role in early development.[UniProtKB/Swiss-Prot Function]

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