Mouse Npc2 activation kit by CRISPRa

CAT#: GA207613

Npc2 CRISPRa kit - CRISPR gene activation of mouse NPC intracellular cholesterol transporter 2



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

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经常一起买 (1)
Goat Anti-Npc2 (mouse) (aa21-33) Antibody
    • 100 ug

CNY 5,371.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol Npc2
Locus ID 67963
Kit Components

GA207613G1, Npc2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA207613G2, Npc2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA207613G3, Npc2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_023409
Synonyms 2700012J19Rik; AA408070; AU045843; HE1
Summary Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:12591949, PubMed:17018531, PubMed:21315718, PubMed:26296895). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (PubMed:21315718).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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