Mouse Lypd1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Lypd1
Locus ID	72585
Kit Components	GA209284G1, Lypd1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209284G2, Lypd1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209284G3, Lypd1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001311089, NM_001311090, NM_145100
Synonyms	2700050C12Rik; AI853408; C530008O16Rik; Lynx2; Lypdc1
Summary	Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs (PubMed:19246390). May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface (PubMed:26276394, PubMed:25716842). May be involved in the control of anxiety (PubMed:19246390).[UniProtKB/Swiss-Prot Function]

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