Mouse Rftn2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rftn2
Locus ID	74013
Kit Components	GA209673G1, Rftn2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209673G2, Rftn2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209673G3, Rftn2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_028713, NM_001356287, NM_001356288
Synonyms	2700010E02Rik; 3222401M22Rik
Summary	Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195). May regulate B-cell antigen receptor-mediated signaling.[UniProtKB/Swiss-Prot Function]

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