Mouse Adhfe1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Adhfe1
Locus ID	76187
Kit Components	GA210452G1, Adhfe1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210452G2, Adhfe1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210452G3, Adhfe1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_175236, NR_027664, NM_001357376, NM_001357377, NM_001357378
Synonyms	6330565B14Rik; Adh8; AI043035
Summary	Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity).[UniProtKB/Swiss-Prot Function]

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