Mouse Vipas39 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Vipas39
Locus ID	104799
Kit Components	GA211836G1, Vipas39 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211836G2, Vipas39 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211836G3, Vipas39 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001142580, NM_001142581, NM_134044
Synonyms	6720456H09Rik; 9330175H22Rik; AI413782; hSPE-39; SPE-39; Spe39; Vipar
Summary	Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B (By similarity). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin.[UniProtKB/Swiss-Prot Function]

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