Mouse Grm5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Grm5
Locus ID	108071
Kit Components	GA212078G1, Grm5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212078G2, Grm5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212078G3, Grm5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001081414, NM_001143834, NM_001033224
Synonyms	6430542K11Rik; AI850523; Glu5R; Gprc1e; mGluR5; mGluR5b
Summary	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity (By similarity).[UniProtKB/Swiss-Prot Function]

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