Mouse Rnf216 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rnf216
Locus ID	108086
Kit Components	GA212085G1, Rnf216 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212085G2, Rnf216 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212085G3, Rnf216 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_080561, NM_207110, NM_001359851
Synonyms	2810055G22Rik; AI647468; AU019462; C86502; F830018F18Rik; TRIAD3; Ubce7ip1; UIP83
Summary	Acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Promotes TNF and RIP mediated apoptosis.[UniProtKB/Swiss-Prot Function]

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