Mouse Nlgn1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nlgn1
Locus ID	192167
Kit Components	GA212695G1, Nlgn1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212695G2, Nlgn1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212695G3, Nlgn1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001163387, NM_138666, NM_001357095, NM_001357096, NM_001357097
Synonyms	6330415N05Rik; BB179718; mKIAA1070; NL1; Nlg1
Summary	Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (PubMed:23716671).[UniProtKB/Swiss-Prot Function]

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