Mouse Mcrip1 activation kit by CRISPRa
CAT#: GA212697
Mcrip1 CRISPRa kit - CRISPR gene activation of mouse MAPK regulated corepressor interacting protein 1
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Mcrip1 |
Locus ID | 192173 |
Kit Components | GA212697G1, Mcrip1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212697G2, Mcrip1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212697G3, Mcrip1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001033231 |
Synonyms | Mcrip1 |
Summary | The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition.[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
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