Mouse Safb activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Safb
Locus ID	224903
Kit Components	GA213740G1, Safb gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213740G2, Safb gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213740G3, Safb gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001163300
Synonyms	3110021E02Rik; 5330423C17Rik; AU018122; D18386; E130307D12; HAP; HET; SAF-B1; SAFB1
Summary	Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. Can inhibit cell proliferation. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter.[UniProtKB/Swiss-Prot Function]

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