Mouse Smg7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Smg7
Locus ID	226517
Kit Components	GA213865G1, Smg7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213865G2, Smg7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213865G3, Smg7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001005507, NM_001160256, NM_001160257, NM_001359257
Synonyms	9430023P16Rik; mKIAA0250
Summary	Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity).[UniProtKB/Swiss-Prot Function]

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