Mouse Madd activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Madd
Locus ID	228355
Kit Components	GA213997G1, Madd gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213997G2, Madd gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213997G3, Madd gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001177719, NM_001177720, NM_001177721, NM_001177722, NM_001177723, NM_001177724, NM_001177725, NM_001177726, NM_001177727, NM_001177728, NM_001177729, NM_145527
Synonyms	9630059K23Rik; IG20
Summary	Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis).[UniProtKB/Swiss-Prot Function]

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