Mouse Serpinb1b activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Serpinb1b
Locus ID	282663
Kit Components	GA216198G1, Serpinb1b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216198G2, Serpinb1b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216198G3, Serpinb1b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_173052
Synonyms	6330533H24Rik; EIB; ovalbumin; Serpin1b1
Summary	Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G (PubMed:12189154). During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621).[UniProtKB/Swiss-Prot Function]

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