TWEAKR (TNFRSF12A) Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Donor DNA	GFP-puro
Symbol	TWEAKR
Locus ID	51330
Kit Components	KN201041G1, TWEAKR gRNA vector 1 in pCas-Guide CRISPR vector, Target Sequence: GGAGCAAGCGCCAGGTACGC KN201041G2, TWEAKR gRNA vector 2 in pCas-Guide CRISPR vector, Target Sequence: GCTCGCTGCGCCGGTTGCTG KN201041-D, donor DNA containing left and right homologous arms and GFP-puro functional cassette. Homologous arm and GFP-puro sequences (showhide) pUC vector backbone in gray; Left arm sequence in blue; GFP-puro in green; Right arm in violet TCACTCTGTC GCCCAGGCTG GAGTGTAGTG GCGCGATCTC GGCTCACTGC AACTTCTGCC TCCCGGGTTC AAGAGATTCT CCTGCCTCAG CCTCCTGAGT AGCTCGGATT GCAGGCGCGC GCCACCACGC CCGGCTAATT TTTGTATTTC GAGTAGAGAC GGCGTTTCAC CACGTTGGTC AGGCTGCTCT CGAACTCCTG ACCTCGTAAT CCGCCTGCCT CAGACTCCCA AACTGATGGG ATTAAAGGCG TGAGCCACCG CGTCCGGCCG TTCGTGTCTG ATTTCTATAT GTGCTGCCGA AGCGAGCACT CGTGTCTAAT TTTTGATTTC CCCACACCAC GCACGCTGGA CTAGATCACC GGCTGGGCAA GGAAGGGGGT CTGCGTCCCT GCGGGGTCCT GGCAGCTCCC GCGCCAGGAC TTTGTTGAAT GAATGACTGA ACTGAGCGGG CGCCGCGGGG CGGGGCGTCC CGAAGCGGAC CTCAAGGCGG GCGGAGGCGA GAGCTCCGCC CCGGAAGGCG GGGGCGGGGG CGGGGCGGCG GCCGTGGGTC CCTGCCGGCC GGCGGCGGGC GCAGACAGCG GCGGGCGCAG GACGTGCACT GGGACTCCGG GGTCGGGGAA CCCCGGGCCG GGGCTCGGGA GCCGGACTGG GTGTCTGGAG AACAGCGCCG AACTGGGGGA ACAGGCGGAT GTGGGGATCT GGGGTCAGGT GGCCTTCAAA CAGCTCGCTC CCGGCTGTGG GAAGTTCCAT CACTCTCCAA GCTTCATTCA CAATCCGGGC CTCAGTTTCT CCCACCGTCC AATTGGGGTT GGGGGGGGTC TTCAGTTCCA CAAGTCCGAA GTACTTCGAA TGGAGAGAGA AAGTGAGTGA GGGCGGGATG TTTAGTCTAG GAAGGGGCAC GCCCCCAGCC TGGTCCGTAC AGGGTCTAAC TAGCCCCAGT GATCGACGAG TTGGGGAGGC CGTCGAGAGG CACTAGGGTC TGTGCCCTCT ATACCATGTG GGGTGCCCCC TTCCATCCGG TGACTTCAGT GCCCAGCTAT GCGGGGGGAG GGACTGGGGT CGGGCCCGGT GCCCAGGAGT GAGTCACCCG CCGGCGGCAG GGGGGTTGTG GGGACCTGAC CCCCCCCACC CCCAGCGTCC CGCGCTACGC CCTCCCTCCC GGAGCTGCCG TGTCCCGGTC GGGCCGTGCG GTCACCTGTG GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_016639
Synonyms	CD266; FN14; TWEAKR
Summary	Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.[UniProtKB/Swiss-Prot Function]

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