Calcipressin 1 (RCAN1) Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Donor DNA	mBFP-Neo
Symbol	Calcipressin 1
Locus ID	1827
Kit Components	KN202391G1, Calcipressin 1 gRNA vector 1 in pCas-Guide CRISPR vector KN202391G2, Calcipressin 1 gRNA vector 2 in pCas-Guide CRISPR vector KN202391BN-D, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_001285389, NM_001285391, NM_001285392, NM_001285393, NM_001331016, NM_004414, NM_203417, NM_203418
Synonyms	ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1
Summary	The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

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