BMAL1 (ARNTL) Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Donor DNA	mBFP-Neo
Symbol	BMAL1
Locus ID	406
Kit Components	KN204464G1, BMAL1 gRNA vector 1 in pCas-Guide CRISPR vector KN204464G2, BMAL1 gRNA vector 2 in pCas-Guide CRISPR vector KN204464BN-D, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_001030272, NM_001030273, NM_001178, NM_001297719, NM_001297722, NM_001297724, NM_001351804, NM_001351805, NM_001351806, NM_001351807, NM_001351808, NM_001351809, NM_001351810, NM_001351811, NM_001351812, NM_001351813, NM_001351814, NM_001351815, NM_001351816, NM_001351817, NM_001351818, NM_001351819, NM_001351820, NM_001351821, NM_001351822, NM_001351823, NM_001351824, NR_147785, NR_147786, NR_147787, NR_147788, NR_147789, NR_147790, NR_147791
Synonyms	bHLHe5; BMAL1; BMAL1c; JAP3; MOP3; PASD3; TIC
Summary	The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

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