Tyrosine Hydroxylase (TH) Human Gene Knockout Kit (CRISPR)

CAT#: KN211218BN

TH - human gene knockout kit via CRISPR, HDR mediated




 HDR-mediated knockout kit validation

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CNY 12,260.00


货期*
6周

规格
    • 1 kit

Product images

经常一起买 (3)
pCAS-Scramble, pCas-Guide vector with a scrambled sequence as a negative control (10 µg)
    • 10 ug

CNY 3,710.00


TH mouse monoclonal antibody, clone OTI1A10 (formerly 1A10)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


TH (Myc-DDK-tagged)-Human tyrosine hydroxylase (TH), transcript variant 2
    • 10 ug

CNY 3,656.00
CNY 3,990.00

Specifications

Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Donor DNA mBFP-Neo
Symbol Tyrosine Hydroxylase
Locus ID 7054
Kit Components

KN211218G1, Tyrosine Hydroxylase gRNA vector 1 in pCas-Guide CRISPR vector

KN211218G2, Tyrosine Hydroxylase gRNA vector 2 in pCas-Guide CRISPR vector

KN211218BN-D, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000360, NM_199292, NM_199293
Synonyms DYT5b; DYT14; TYH
Summary The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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