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LDL Receptor (LDLR) (NM_000527) Human Mass Spec Standard
CAT＃: PH300006
LDLR MS Standard C13 and N15-labeled recombinant protein (NP_000518)
View other "LDL Receptor" proteins (8)
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CNY 19,520.00
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CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Description | LDLR MS Standard C13 and N15-labeled recombinant protein (NP_000518) |
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC200006 |
| Predicted MW | 95.38 kDa |
| Protein Sequence |
>RC200006 representing NM_000527
Red=Cloning site Green=Tags(s) MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKS GDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDE ASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECI HSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPN KFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQR RCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYW TDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENI QWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFS ANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPD GMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQ ALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH NQDGYSYPSRQMVSLEDDVA TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Tag | C-Myc/DDK |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Reference Data | |
| RefSeq | NP_000518 |
| RefSeq Size | 5175 |
| RefSeq ORF | 2580 |
| Synonyms | FH; FHC; FHCL1; LDLCQ2 |
| Locus ID | 3949 |
| Cytogenetics | 19p13.2 |
| Summary | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Endocytosis |
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Other Versions
| SKU | Description | Size | Price |
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| LC400183 | LDLR HEK293T cell transient overexpression lysate (as WB positive control) |
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| LC434371 | LDLR HEK293T cell transient overexpression lysate (as WB positive control) |
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| LC434377 | LDLR HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
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| LY400183 | Transient overexpression lysate of low density lipoprotein receptor (LDLR) |
CNY 3,080.00 |
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| LY434371 | Transient overexpression lysate of low density lipoprotein receptor (LDLR), transcript variant 6 |
CNY 4,840.00 |
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| LY434377 | Transient overexpression lysate of low density lipoprotein receptor (LDLR), transcript variant 4 |
CNY 4,840.00 |
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| TP300006 | Recombinant protein of human low density lipoprotein receptor (LDLR), 20 µg |
CNY 2,900.00 |
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| TP720505 | Recombinant protein of human low density lipoprotein receptor (LDLR), Ala22 - Arg788 |
CNY 3,140.00 |
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