DCXR (NM_016286) Human Mass Spec Standard

Specifications

Product Data
Description	DCXR MS Standard C13 and N15-labeled recombinant protein (NP_057370)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200023
Predicted MW	25.9 kDa
Protein Sequence	Sequence Link (showhide) >RC200023 protein sequence Red=Cloning site Green=Tags(s) MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERA LGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQ RAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFA EVEHVVNAILFLLSDRSGMTTGSTLPVEGGFWAC TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_057370
RefSeq Size	860
RefSeq ORF	732
Synonyms	DCR; HCR2; HCRII; KIDCR; P34H; PNTSU; SDR20C1; XR
Locus ID	51181
Cytogenetics	17q25.3
Summary	The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Pentose and glucuronate interconversions

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