LSM1 (NM_014462) Human Mass Spec Standard

Specifications

Product Data
Description	LSM1 MS Standard C13 and N15-labeled recombinant protein (NP_055277)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200288
Predicted MW	15.2 kDa
Protein Sequence	Sequence Link (showhide) >RC200288 protein sequence Red=Cloning site Green=Tags(s) MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIPRGIFVVRGEN VVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQTKLEAEKLKVQALKDRGLSIPRADTLDEY TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_055277
RefSeq Size	1161
RefSeq ORF	399
Synonyms	CASM; YJL124C
Locus ID	27257
Cytogenetics	8p11.23
Summary	This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]
Protein Families	Stem cell - Pluripotency
Protein Pathways	RNA degradation

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