NOLC1 (NM_004741) Human Mass Spec Standard

CAT#: PH300356

NOLC1 MS Standard C13 and N15-labeled recombinant protein (NP_004732)



  View other "NOLC1" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description NOLC1 MS Standard C13 and N15-labeled recombinant protein (NP_004732)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC200356
Predicted MW 73.7 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_004732
RefSeq Size 3947
RefSeq ORF 2100
Synonyms NOPP130; NOPP140; NS5ATP13; P130; Srp40
Locus ID 9221
Cytogenetics 10q24.32
Summary Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786).[UniProtKB/Swiss-Prot Function]
Protein Families Stem cell - Pluripotency
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