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Apolipoprotein E (APOE) (NM_000041) Human Mass Spec Standard
CAT＃: PH300395
APOE MS Standard C13 and N15-labeled recombinant protein (NP_000032)
View other "Apolipoprotein E" proteins (9)
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CNY 19,520.00
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Specifications
| Product Data | |
| Description | APOE MS Standard C13 and N15-labeled recombinant protein (NP_000032) |
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC200395 |
| Predicted MW | 36.2 kDa |
| Protein Sequence |
>RC200395 protein sequence
Red=Cloning site Green=Tags(s) MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELL SSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEV QAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRA ATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK SWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Tag | C-Myc/DDK |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Reference Data | |
| RefSeq | NP_000032 |
| RefSeq Size | 1223 |
| RefSeq ORF | 951 |
| Synonyms | AD2; APO-E; ApoE4; LDLCQ5; LPG |
| Locus ID | 348 |
| Cytogenetics | 19q13.32 |
| Summary | The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016] |
| Protein Families | Adult stem cells, Druggable Genome, Secreted Protein, Stem cell - Pluripotency |
| Protein Pathways | Alzheimer's disease |
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