UROD (NM_000374) Human Mass Spec Standard

Specifications

Product Data
Description	UROD MS Standard C13 and N15-labeled recombinant protein (NP_000365)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200529
Predicted MW	40.8 kDa
Protein Sequence	Sequence Link (showhide) >RC200529 protein sequence Red=Cloning site Green=Tags(s) MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTL QPLRRFPLDAAIIFSDILVVPQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITL TRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAG AQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVV GLDWTVAPKKARECVGKTVTLQVNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHV GAFVDAVHKHSRLLRQN TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000365
RefSeq Size	1408
RefSeq ORF	1101
Synonyms	PCT; UPD
Locus ID	7389
Cytogenetics	1p34.1
Summary	This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010]
Protein Families	Druggable Genome
Protein Pathways	Porphyrin and chlorophyll metabolism

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