RhoGDI (ARHGDIA) (NM_004309) Human Mass Spec Standard

Specifications

Product Data
Description	ARHGDIA MS Standard C13 and N15-labeled recombinant protein (NP_004300)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200902
Predicted MW	23.2 kDa
Protein Sequence	Sequence Link (showhide) >RC200902 protein sequence Red=Cloning site Green=Tags(s) MAEQEPTAEQLAQIAAENEEDEHSVNYKPPAQKSIQEIQELDKDDESLRKYKEALLGRVAVSADPNVPNV VVTGLTLVCSSAPGPLELDLTGDLESFKKQSFVLKEGVEYRIKISFRVNREIVSGMKYIQHTYRKGVKID KTDYMVGSYGPRAEEYEFLTPVEEAPKGMLARGSYSIKSRFTDDDKTDHLSWEWNLTIKKDWKD TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_004300
RefSeq Size	1920
RefSeq ORF	612
Synonyms	GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1
Locus ID	396
Cytogenetics	17q25.3
Summary	This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Protein Families	Druggable Genome
Protein Pathways	Neurotrophin signaling pathway

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