NEIL2 (NM_145043) Human Mass Spec Standard

CAT#: PH300913

NEIL2 MS Standard C13 and N15-labeled recombinant protein (NP_659480)



  View other "NEIL2" proteins (9)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of nei like 2 (E. coli) (NEIL2), transcript variant 1
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NEIL2 Antibody - N-terminal region
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Specifications

Product Data
Description NEIL2 MS Standard C13 and N15-labeled recombinant protein (NP_659480)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC200913
Predicted MW 36.8 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_659480
RefSeq Size 2746
RefSeq ORF 996
Synonyms NEH2; NEI2
Locus ID 252969
Cytogenetics 8p23.1
Summary This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]
Protein Families Druggable Genome
Protein Pathways Base excision repair
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