Noxa (PMAIP1) (NM_021127) Human Mass Spec Standard

Specifications

Product Data
Description	PMAIP1 MS Standard C13 and N15-labeled recombinant protein (NP_066950)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC202071
Predicted MW	5.8 kDa
Protein Sequence	Sequence Link (showhide) >RC202071 representing NM_021127 Red=Cloning site Green=Tags(s) MPGKKARKNAQPSPARAPAELEVECATQLRRFGDKLNFRQKLLNLISKLFCSGT TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_066950
RefSeq Size	1885
RefSeq ORF	162
Synonyms	APR; NOXA
Locus ID	5366
Cytogenetics	18q21.32
Summary	This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic BCL-2 family members, which under steady-state conditions keep the multi-BH domain proteins BAX and BAK, in an inactive state. [provided by RefSeq, Aug 2020]
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	p53 signaling pathway

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