SPG3A (ATL1) (NM_015915) Human Mass Spec Standard

Specifications

Product Data
Description	ATL1 MS Standard C13 and N15-labeled recombinant protein (NP_056999)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC202310
Predicted MW	63.4 kDa
Protein Sequence	Sequence Link (showhide) >RC202310 representing NM_015915 Red=Cloning site Green=Tags(s) MAKNRRDRNSWGGFSEKTYEWSSEEEEPVKKAGPVQVLIVKDEHSFELDETALNRILLSEAVRDKEVVAV SVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIWSEIFLINKPDGKKV AVLLMDTQGTFDSQSTLRDSATVFALSTMISSIQVYNLSQNVQEDDLQHLQLCTEYGRLAMEETFLKPFQ SLIFLVRDWSFPYEFSYGADGGAKFLEKRLKVSGNQHEELQNVRKHIHSCFTNISCFLLPHPGLKVATNP NFDGKLKEIDDEFIKNLKILIPWLLSPESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPKSMLQA TAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGVKKMGGEEFSRRYLQQ LESEIDELYIQYIKHNDSKNIFHAARTPATLFVVIFITYVIAGVTGFIGLDIIASLCNMIMGLTLITLCT WAYIRYSGEYRELGAVIDQVAAALWDQGSTNEALYKLYSAAATHRHLYHQAFPTPKSESTEQSEKKKM TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_056999
RefSeq Size	2271
RefSeq ORF	1674
Synonyms	AD-FSP; atlastin1; FSP1; GBP3; HSN1D; SPG3; SPG3A
Locus ID	51062
Cytogenetics	14q22.1
Summary	The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Transmembrane

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