PAR4 (PAWR) (NM_002583) Human Mass Spec Standard

CAT#: PH302733

PAWR MS Standard C13 and N15-labeled recombinant protein (NP_002574)



  View other "PAR4" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description PAWR MS Standard C13 and N15-labeled recombinant protein (NP_002574)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC202733
Predicted MW 36.6 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_002574
RefSeq Size 1967
RefSeq ORF 1020
Synonyms Par-4; PAR4
Locus ID 5074
Cytogenetics 12q21.2
Summary This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]
Protein Families Druggable Genome, Transcription Factors
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