Ketosamine 3 kinase (FN3KRP) (NM_024619) Human Mass Spec Standard

Specifications

Product Data
Description	FN3KRP MS Standard C13 and N15-labeled recombinant protein (NP_078895)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC203554
Predicted MW	34.4 kDa
Protein Sequence	Sequence Link (showhide) >RC203554 protein sequence Red=Cloning site Green=Tags(s) MEELLRRELGCSSVRATGHSGGGCISQGRSYDTDQGRVFVKVNPKAEARRMFEGEMASLTAILKTNTVKV PKPIKVLDAPGGGSVLVMEHMDMRHLSSHAAKLGAQLADLHLDNKKLGEMRLKEAGTVGRGGGQEERPFV ARFGFDVVTCCGYLPQVNDWQEDWVVFYARQRIQPQMDMVEKESGDREALQLWSALQLKIPDLFRDLEII PALLHGDLWGGNVAEDSSGPVIFDPASFYGHSEYELAIAGMFGGFSSSFYSAYHGKIPKAPGFEKRLQLY QLFHYLNHWNHFGSGYRGSSLNIMRNLVK TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_078895
RefSeq Size	1844
RefSeq ORF	927
Synonyms	FN3KL
Locus ID	79672
Cytogenetics	17q25.3
Summary	A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Protein Families	Druggable Genome

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