LTA (NM_000595) Human Mass Spec Standard

Specifications

Product Data
Description	LTA MS Standard C13 and N15-labeled recombinant protein (NP_000586)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC203741
Predicted MW	22.3 kDa
Protein Sequence	Sequence Link (showhide) >RC203741 protein sequence Red=Cloning site Green=Tags(s) MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGD PSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSS QYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000586
RefSeq Size	1423
RefSeq ORF	615
Synonyms	LT; TNFB; TNFSF1; TNLG1E
Locus ID	4049
Cytogenetics	6p21.33
Summary	The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Antigen processing and presentation, Cytokine-cytokine receptor interaction, Type I diabetes mellitus

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