Kindlin 2 (FERMT2) (NM_006832) Human Mass Spec Standard

CAT#: PH305727

FERMT2 MS Standard C13 and N15-labeled recombinant protein (NP_006823)



  View other "Kindlin 2" proteins (5)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description FERMT2 MS Standard C13 and N15-labeled recombinant protein (NP_006823)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC205727
Predicted MW 77.9 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_006823
RefSeq Size 3351
RefSeq ORF 2040
Synonyms KIND2; mig-2; MIG2; PLEKHC1; UNC112; UNC112B
Locus ID 10979
Cytogenetics 14q22.1
Summary Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.[UniProtKB/Swiss-Prot Function]
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