PPP1R14A (NM_033256) Human Mass Spec Standard

Specifications

Product Data
Description	PPP1R14A MS Standard C13 and N15-labeled recombinant protein (NP_150281)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC205799
Predicted MW	16.7 kDa
Protein Sequence	Sequence Link (showhide) >RC205799 protein sequence Red=Cloning site Green=Tags(s) MAAQRLGKRVLSKLQSPSRARGPGGSPGGLQKRHARVTVKYDRRELQRRLDVEKWIDGRLEELYRGMEAD MPDEINIDELLELESEEERSRKIQGLLKSCGKPVEDFIQELLAKLQGLHRQPGLRQPSPSHDGSLSPLQD RARTAHP TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_150281
RefSeq Size	782
RefSeq ORF	441
Synonyms	CPI-17; CPI17; PPP1INL
Locus ID	94274
Cytogenetics	19q13.2
Summary	The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]
Protein Families	Druggable Genome
Protein Pathways	Vascular smooth muscle contraction

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