Neurofilament (NEFL) (NM_006158) Human Mass Spec Standard

CAT#: PH305920

NEFL MS Standard C13 and N15-labeled recombinant protein (NP_006149)



  View other "Neurofilament" proteins (6)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

Cited in 2 publications.

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Specifications

Product Data
Description NEFL MS Standard C13 and N15-labeled recombinant protein (NP_006149)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC205920
Predicted MW 61.5 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_006149
RefSeq Size 3854
RefSeq ORF 1629
Synonyms CMT1F; CMT2E; CMTDIG; NF-L; NF68; NFL; PPP1R110
Locus ID 4747
Cytogenetics 8p21.2
Summary Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]
Protein Families Druggable Genome, ES Cell Differentiation/IPS
Protein Pathways Amyotrophic lateral sclerosis (ALS)
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Citations (2)

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