NISCH (NM_007184) Human Mass Spec Standard

CAT#: PH306026

NISCH MS Standard C13 and N15-labeled recombinant protein (NP_009115)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

Cited in 1 publication.

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Specifications

Product Data
Description NISCH MS Standard C13 and N15-labeled recombinant protein (NP_009115)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC206026
Predicted MW 166.7 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_009115
RefSeq Size 5252
RefSeq ORF 4512
Synonyms hIRAS; I-1; IR1; IRAS
Locus ID 11188
Cytogenetics 3p21.1
Summary This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]
Protein Families Druggable Genome
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Citations (1)

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