FRMD8 (NM_031904) Human Mass Spec Standard

CAT#: PH307879

FRMD8 MS Standard C13 and N15-labeled recombinant protein (NP_114110)



  View other "FRMD8" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (1)
Transient overexpression lysate of FERM domain containing 8 (FRMD8)
    • 100 ug

CNY 3,080.00

Specifications

Product Data
Description FRMD8 MS Standard C13 and N15-labeled recombinant protein (NP_114110)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC207879
Predicted MW 51.2 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_114110
RefSeq Size 3774
RefSeq ORF 1392
Synonyms FKSG44; iTAP
Locus ID 83786
Cytogenetics 11q13.1
Summary Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019).[UniProtKB/Swiss-Prot Function]
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