ERG (NM_182918) Human Mass Spec Standard

CAT#: PH308093

ERG MS Standard C13 and N15-labeled recombinant protein (NP_891548)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description ERG MS Standard C13 and N15-labeled recombinant protein (NP_891548)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC208093
Predicted MW 53.7 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_891548
RefSeq Size 3055
RefSeq ORF 1437
Synonyms erg-3; p55
Locus ID 2078
Cytogenetics 21q22.2
Summary This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Protein Families Druggable Genome, Transcription Factors
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