CA8 (NM_004056) Human Mass Spec Standard

CAT#: PH310228

CA8 MS Standard C13 and N15-labeled recombinant protein (NP_004047)



  View other "CA8" proteins (4)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description CA8 MS Standard C13 and N15-labeled recombinant protein (NP_004047)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC210228
Predicted MW 33 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_004047
RefSeq Size 2278
RefSeq ORF 870
Synonyms CA-RP; CA-VIII; CALS; CAMRQ3; CARP
Locus ID 767
Cytogenetics 8q12.1
Summary The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Protein Families Druggable Genome
Protein Pathways Nitrogen metabolism
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