MADH7 (SMAD7) (NM_005904) Human Mass Spec Standard

CAT#: PH310400

SMAD7 MS Standard C13 and N15-labeled recombinant protein (NP_005895)



  View other "MADH7" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
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    • 100 ul

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Specifications

Product Data
Description SMAD7 MS Standard C13 and N15-labeled recombinant protein (NP_005895)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC210400
Predicted MW 46.2 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_005895
RefSeq Size 3103
RefSeq ORF 1278
Synonyms CRCS3; MADH7; MADH8
Locus ID 4092
Cytogenetics 18q21.1
Summary The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Protein Families Druggable Genome, Transcription Factors
Protein Pathways TGF-beta signaling pathway
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