Estrogen Receptor 1 (ESR1) (NM_000125) Human Mass Spec Standard

CAT#: PH313277

ESR1 MS Standard C13 and N15-labeled recombinant protein (NP_000116)



  View other "Estrogen Receptor 1" proteins (14)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description ESR1 MS Standard C13 and N15-labeled recombinant protein (NP_000116)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC213277
Predicted MW 66.2 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000116
RefSeq Size 6456
RefSeq ORF 1785
Synonyms ER; Era; ESR; ESRA; ESTRR; NR3A1
Locus ID 2099
Cytogenetics 6q25.1-q25.2
Summary This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain. [provided by RefSeq, Jul 2020]
Protein Families Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
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