PGPEP1 (NM_017712) Human Mass Spec Standard

Specifications

Product Data
Description	PGPEP1 MS Standard C13 and N15-labeled recombinant protein (NP_060182)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC214837
Predicted MW	23 kDa
Protein Sequence	Sequence Link (showhide) >RC214837 representing NM_017712 Red=Cloning site Green=Tags(s) MEQPRKAVVVTGFGPFGEHTVNASWIAVQELEKLGLGDSVDLHVYEIPVEYQTVQRLIPALWEKHSPQLV VHVGVSGMATTVTLEKCGHNKGYKGLDNCRFCPGSQCCVEDGPESIDSIIDMDAVCKRVTTLGLDVSVTI SQDAGRYLCDFTYYTSLYQSHGRSAFVHVPPLGKPYNADQLGRALRAIIEEMLDLLEQSEGKINYCHKH TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_060182
RefSeq Size	2239
RefSeq ORF	627
Synonyms	PAP-I; Pcp; PGI; PGP; PGP-I; PGPI
Locus ID	54858
Cytogenetics	19p13.11
Summary	The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]
Protein Families	Druggable Genome, Protease

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