Thyroglobulin (TG) (NM_003235) Human Mass Spec Standard

CAT#: PH316216

TG MS Standard C13 and N15-labeled recombinant protein (NP_003226)



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CNY 14,250.00


货期*
5周

规格
    • 10 ug

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经常一起买 (1)
TG mouse monoclonal antibody,clone OTI8E1
    • 100 ul

CNY 1,999.00
CNY 2,700.00

Specifications

Product Data
Description TG MS Standard C13 and N15-labeled recombinant protein (NP_003226)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC216216
Predicted MW 304.8 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_003226
RefSeq Size 8453
RefSeq ORF 8304
Synonyms AITD3; TGN
Locus ID 7038
Cytogenetics 8q24.22
Summary Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
Protein Families Druggable Genome
Protein Pathways Autoimmune thyroid disease
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