Presenilin 1 (PSEN1) (NM_000021) Human Mass Spec Standard

CAT#: PH316443

PSEN1 MS Standard C13 and N15-labeled recombinant protein (NP_000012)



  View other "Presenilin 1" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of presenilin 1 (PSEN1), transcript variant 1
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PSEN1 Antibody - middle region
    • 100 ul

CNY 5,250.00

Specifications

Product Data
Description PSEN1 MS Standard C13 and N15-labeled recombinant protein (NP_000012)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC216443
Predicted MW 52.5 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000012
RefSeq Size 2763
RefSeq ORF 1401
Synonyms ACNINV3; AD3; FAD; PS-1; PS1; S182
Locus ID 5663
Cytogenetics 14q24.2
Summary Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Protein Families Druggable Genome, Protease, Transmembrane
Protein Pathways Alzheimer's disease, Neurotrophin signaling pathway, Notch signaling pathway, Wnt signaling pathway
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