Prostaglandin D Synthase (PTGDS) (NM_000954) Human Mass Spec Standard

Specifications

Product Data
Description	PTGDS MS Standard C13 and N15-labeled recombinant protein (NP_000945)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC216795
Predicted MW	20.8 kDa
Protein Sequence	Sequence Link (showhide) >RC216795 representing NM_000954 Red=Cloning site Green=Tags(s) MATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVA PATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPG EDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCMTEQ TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000945
RefSeq Size	837
RefSeq ORF	570
Synonyms	L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2
Locus ID	5730
Cytogenetics	9q34.3
Summary	The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]
Protein Pathways	Arachidonic acid metabolism, Metabolic pathways

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