TSH beta (TSHB) (NM_000549) Human Mass Spec Standard

Specifications

Product Data
Description	TSHB MS Standard C13 and N15-labeled recombinant protein (NP_000540)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC216914
Predicted MW	15.61 kDa
Protein Sequence	Sequence Link (showhide) >RC216914 representing NM_000549 Red=Cloning site Green=Tags(s) MTALFLMSMLFGLACGQAMSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQD VCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYLVGFSV TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000540
RefSeq Size	578
RefSeq ORF	414
Synonyms	TSH-B; TSH-BETA
Locus ID	7252
Cytogenetics	1p13.2
Summary	The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Autoimmune thyroid disease, Neuroactive ligand-receptor interaction

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