FLIP (CFLAR) (NM_001127184) Human Mass Spec Standard

Specifications

Product Data
Description	CFLAR MS Standard C13 and N15-labeled recombinant protein (NP_001120656)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC225270
Predicted MW	25.2 kDa
Protein Sequence	Sequence Link (showhide) >RC225270 representing NM_001127184 Red=Cloning site Green=Tags(s) MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLYRVRRFDLLKR ILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEK LNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNNFRMITPYAHC PDLKILGNCSM TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_001120656
RefSeq ORF	663
Synonyms	c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT
Locus ID	8837
Cytogenetics	2q33.1
Summary	The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Protein Families	Druggable Genome, Protease
Protein Pathways	Apoptosis

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