Cardiac Troponin I Human Protein
CNY 7,810.00
货期*
详询
规格
Product images
Specifications
Product Data | |
Description | Cardiac Troponin I human protein, 10 µg |
Species | Human |
Protein Source | Cardiac muscle |
Concentration | lot specific |
Purity | >95% by SDS-PAGE |
Buffer | State: Liquid Buffer System: 7M Urea, 5 mM EDTA, 20 mM Tris Preservative: 15 mM Mercaptoethanol |
Preparation | Liquid |
Applications | ELISA. |
Protein Description | Purified native Human Troponin I from Human heart |
Note | Caution: Blood samples of the tissue donor for this product was tested and found negative for HBsAg, HCV, syphillis and HIV-I and HIV-II antibodies. Nevertheless, all products from human sources should be handled as potentially infectious. |
Storage | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_000354 |
Locus ID | 7137 |
Cytogenetics | 19q13.42 |
Synonyms | CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1 |
Summary | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020] |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency |
Protein Pathways | Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM) |
Documents
Customer
Reviews
Loading...